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Analytical Chemistry and Instrumentation Theory (CHEM 2410)
Total Credits:
3
Lecture Credits:
3
Description:
This lecture course introduces the principles of analytical methods and instrumentation. You will learn the theories of various chemical and biochemical methods of analyses. You will explore the principles of ionic equilibria, acid-base, complexometric, redox and electro analytical techniques. You will gain an understanding of various instruments including spectroscopic and chromatographic methods. You will appreciate the application of analytical chemistry in meeting the regulatory requirements of Food and Drug Administration and Environmental Protection Agency in a variety of industrial and research applications. You will learn about HVAC requirements in clean-room environments and develop the necessary skills to document and statistically analyze data.
Topical Outline:
1. Scope of analytical chemistry applications in multiple disciplines, as well as diverse industry and government labs, and in meeting FDA’s cGMP/GLP, PAT, CMCs, and ISO 17025 requirements
2. Chemical measurements and statistics in analytical chemistry (as applied to chemical concentrations, stoichiometry, quantitative analysis, error analysis, Statistical treatment of data, spreadsheets)
3. Analytical process and factors to consider in analytical methods development, their validations and quality assurance
4. Applications of chemical equilibrium, gravimetric, volumetric (acid-base, complexation) and electrochemical (potentiometric and redox) analysis
5. Spectroscopy and chromatography principles and associated instrumentation (VIS, UV, IR, luminescence, atomic absorption, GC, TLC, HPLC)
6. Scientific literature and science Writing-Intensive experiences (exploration of scientific literature databases for primary literature on analytical methods on a chosen application, and their analysis to write a research review report)
Learning Outcomes:
1. Identify analytical chemistry applications in diverse disciplines, environmental and societal importance, and be able to explain how analytical chemistry will be used in their own field of interest
2. Carry out mathematical calculations in chemical measurements and statistical treatment of data (precision, accuracy, confidence intervals, t-, F- and G-tests, etc.), spreadsheets usage
3. Recognize the significance of analytical chemistry and instrumentation in the context of regulatory requirements of EPA, and expectations of FDA and ISO in regulated workplaces
4. Interpret and apply aqueous solution speciation (in precipitation, acid-base, redox, and complexation scenarios) for analysis of unknowns
5. Apply basic principles of spectroscopic and chromatographic methods of analysis and identify the capabilities and limitations of these methods
6. Exhibit critical thinking, problem solving and written communication skills (through diverse situations of analytical sampling, method development, their validations, and analysis of published primary articles of research for scientific review report)
Prerequisites:
CHEM 1152 or
CHEM 2320
Co-requisites:
CHEM 2420